2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W751669
    9-Fluorenol-d9
    9-Fluorenol-d9 (9-Hydroxyfluorene-d9) is the deuterium labeled 9-Fluorenol (HY-W016388). 9-Fluorenol (9-Hydroxyfluorene; compound 3) is a dopamine (DAT) inhibitor with IC50 value of 9 μM. 9-Fluorenol is a major metabolite of compound developed as a wake promoting agent. 9-Fluorenol shows wake promotion activity in vivo.
    9-Fluorenol-d<sub>9</sub>
  • HY-W742805
    Sulindac Sulfone-d6
    Sulindac Sulfone-d6 is the deuterium labeled Sulindac sulfone (HY-B1787). Sulindac sulfone is an mTORC1 pathway inhibitor and a metabolite of Sulindac. Sulindac sulfone inhibits colon cancer cell growth and induces cell cycle arrest. Sulindac sulfone is used in cancer research.
    Sulindac Sulfone-</sub>d<sub>6</sub>
  • HY-129491S
    O-Desmethyl Midostaurin-d5
    O-Desmethyl Midostaurin-d5 is a deuterium labeled O-Desmethyl PKC412. O-Desmethyl Midostaurin (CGP62221; O-Desmethyl PKC412) is the active metabolite of Midostaurin (HY-10230) via cytochrome P450 liver enzyme metabolism.
    O-Desmethyl Midostaurin-d<sub>5</sub>
  • HY-169046
    (±)13,14-DiHDoTrE
    (±)13,14-DiHDoTrE ((±)13,14-DHDT) is an oxylipin and a metabolite of Adrenic acid (HY-W013215).
    (±)13,14-DiHDoTrE
  • HY-138166R
    Rosuvastatin lactone (Standard)
    Rosuvastatin lactone (Standard) is the analytical standard of Rosuvastatin lactone. This product is intended for research and analytical applications. Rosuvastatin lactone is a metabolite of Rosuvastatin (HY-17504A), a statin lipid-lowering agent and HMG-CoA inhibitor. Rosuvastatin lactone exhibits endothelium-independent and HMG-CoA reductase-independent vasorelaxant activity in rat aortic rings, and its vasorelaxant effect is jointly mediated by NO produced by inducible nitric oxide synthase (iNOS) located in vascular smooth muscle and activation of potassium channels. Rosuvastatin lactone itself has no lipid-lowering effect.
    Rosuvastatin lactone (Standard)
  • HY-178286
    Avitinib-methyl
    Avitinib-methyl is the metabolite of Avitinib (HY-19816).
    Avitinib-methyl
  • HY-147323R
    Ferulic acid 4-O-sulfate (Standard)
    Ferulic acid 4-O-sulfate (Standard) is the analytical standard of Ferulic acid 4-O-sulfate. This product is intended for research and analytical applications. Ferulic acid 4-O-sulfate (Ferulic acid 4-sulfate) is a metabolite of Ferulic acid (HY-N0060). Ferulic acid 4-O-sulfate relaxes arteries and lowers blood pressure in mice[1].
    Ferulic acid 4-O-sulfate (Standard)
  • HY-G0016
    N-Acetyl dapsone
    N-Acetyl dapsone (MADDS) is the major metabolite of Dapsone (HY-B0688). Dapsone is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities.
    N-Acetyl dapsone
  • HY-15793A
    Trans (2,3)-Dihydrotetrabenazine
    Trans (2,3)-Dihydrotetrabenazine ((2R,3R,11bR)-rel-Dihydrotetrabenazine), a metabolite of Tetrabenazine, shows remarkable inhibition activity on vesicular monoamine transporter (VMAT2).
    Trans (2,3)-Dihydrotetrabenazine
  • HY-N18019
    Tetrahydro bellidifolin
    Tetrahydro bellidifolin (Compound 1a) is the aglycone obtained from the hydrolysis of Tetrahydroswertianolin (HY-N18018) by β-glucosidase. Tetrahydro bellidifolin exhibits significant hepatoprotective activity and reduce serum ALT levels. Tetrahydro bellidifolin can be used for the research of liver injury.
    Tetrahydro bellidifolin
  • HY-144203S
    Trospium EP impurity C-d8 chloride
    Trospium EP impurity C-d8 (chloride) is the deuterium labeled Trospium EP impurity C chloride.
    Trospium EP impurity C-d<sub>8</sub> chloride
  • HY-133787R
    Levofloxacin N-oxide (Standard)
    Levofloxacin N-oxide (Standard) is the analytical standard of Levofloxacin N-oxide. This product is intended for research and analytical applications. Levofloxacin N-oxide is a minor metabolite of Levofloxacin (HY-B0330). Levofloxacin N-oxide does not exhibit significantly genotoxic risks. Levofloxacin is an orally active antibiotic and is active against both Gram-positive and Gram-negative bacteria.
    Levofloxacin N-oxide (Standard)
  • HY-W585893
    Endrin ketone
    Endrin ketone is an Endrin (HY-W585893) degradation product. Endrin is a carcinogen.
    Endrin ketone
  • HY-N15575
    Rhamnitol
    Rhamnitol is the reduction product of L-rhamnose that can be found in the metabolism of ingested rhamnose in the body. Rhamnitol is promising for research of intestinal permeability assessment and carbohydrate metabolism.
    Rhamnitol
  • HY-G0001S
    Lurasidone Metabolite 14283-d8
    Lurasidone Metabolite 14283-d8 is the deuterium labeled Lurasidone Metabolite 14283, which is a metabolite of Lurasidone.
    Lurasidone Metabolite 14283-d<sub>8</sub>
  • HY-32350S
    Ercalcitriol-13C,d3
    Ercalcitriol-13C,d3 is the 13C- and deuterium labeled Ercalcitriol. Ercalcitriol (1α,25-Dihydroxy Vitamin D2) is an active metabolite of vitamin D2.
    Ercalcitriol-<sup>13</sup>C,d<sub>3</sub>
  • HY-101108S
    Tazarotenic acid-d6
    Tazarotenic acid-d6 is deuterium labeled Tazarotenic acid. Tazarotenic acid is the metabolite of Tazarotene. Tazarotenic acid binding to retinoic acid receptors (RARs) is the probable molecular target of retinoid action. Tazarotenic acid has the potential for the research of warty dyskeratoma.
    Tazarotenic acid-d<sub>6</sub>
  • HY-131283
    8-Demethyl Ivabradine
    8-Demethyl Ivabradine is a metabolite of Ivabradine. Ivabradine is an orally bioavailable, hyperpolarization-activated, cyclic nucleotide-gated (HCN) channel blocker.
    8-Demethyl Ivabradine
  • HY-131281
    Ivabradine impurity 1
    Ivabradine impurity 1 is an Ivabradine impurity. Ivabradine is an orally bioavailable, hyperpolarization-activated, cyclic nucleotide-gated (HCN) channel blocker.
    Ivabradine impurity 1
  • HY-160828
    O-Desmethyl dacomitinib
    O-Desmethyl dacomitinib (PF-05199265) is the major circulating metabolite of dacomitinib (HY-13272) and acts as a pan-epidermal growth factor receptor (ErbB) tyrosine kinase inhibitor. O-Desmethyl dacomitinib exhibits a much lower exposure level than dacomitinib in the body. O-Desmethyl dacomitinib is highly dependent on the enzymatic activity of CYP2D6 for its formation.
    O-Desmethyl dacomitinib
Cat. No. Product Name / Synonyms Application Reactivity